时间：9月9日 星期一 上午10：00
　　地点：中国科学院水生生物研究所 3号实验楼2楼学术报告厅
　　报告专家：戴俊彪 研究员 中国科学院深圳先进技术研究院
　　报告题目：Decode and reprogram the yeast genome
　　专家简介：戴俊彪，中国科学院深圳先进技术研究院研究员，博士生导师。主要研究方向是开发基因和基因组的合成、组装及转移技术，通过基因组的设计构建解析基因组功能，并进行合成生物的改造和优化等。近5年以通讯/共同通讯作者身份在Science、Nature Communications、Cell Research、Developmental Cell等杂志发表论文30余篇，研究成果入选2017年度中国科学十大进展。
　　报告内容简介：Facilitated by advances in technologies for DNA synthesis and assembly, the entire genome of an organism, from viruses to bacteria, has now become the target of redesign and reprogramming. The synthesis of first eukaryote, Saccharomyces cerevisiae, genome (Sc2.0) is near completion, tackled by an international consortium. Sets of design features were grafted into the Sc2.0 genome to promote deeper understanding of genome function. For example, a system called synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) is incorporated to probe the structural rule, gene content and plasticity of the yeast genome, which subsequently generated many new discoveries. In this talk, I will review our previous work in synthetic yeast genome and introduce the next version of the designed yeast genome including the construction of a mega-essential chromosome and strategies to build a highly simplified genome.